Skymab Biotherapeutics is a Biotech, a CEA’s spin-off created in 2019 dedicated to the development of GPCR-targeted antibodies in oncology with a strong focus on antibody-drug conjugates (ADCs). Skymab headquarter is based in Tours, 37000, France. Its most advanced and validated candidate is an ADC at preclinical stage and expected to be in phase I clinical trial in cancer patients within the next 2 years. Skymab has the ambition to further discover and develop innovative medicines in oncology.
Skymab offer a unique opportunity to be part of a game changing time of its development and to leverage unprecedented skills and responsibilities in a fast-growing structure. At Skymab, as a biotech startup, we strive for working with a dynamic “can do” attitude. Entrepreneurship, creativity, integrity and cheerfulness are our keystone. We are looking for enthusiastic, talented people who have the ambition to develop themselves and can be of value. If you are interested to grasp the essence of innovation and turn into life changing medicines, join to Skymab’s journey.
The Role & Main Purposes:
· He/she will assist the Director of Development in the execution of the experimental plan in close interactions with the Director of Operations, the Scientific Director and the CEO.
· The main role of the position will consist in building the preclinical data package to complete the non-clinical pharmacology of the regulatory dossier and consolidate the global value proposition of the company.
· He/she will also contribute to move Skymab second candidate to the clinical development path and build the discovery pipeline of anti-GPCR antibodies and ADCs of Skymab.
· He/she will set up and organize in close interactions with the senior scientist, the first R&D laboratory of Skymab.
· He/she will develop and manage in-house R&D activities involving Biolabs platform as well as externalized R&D activities with CROs, private and academic partners with the support of the Director of Development and the Director of Operations.
Key responsibilities of his/her mission include:
· Ensure state of the art design and implementation of controlled preclinical in vitro and in vivo studies to provide POC, selection, characterization, and validation of monoclonal antibodies and ADCs to support preclinical part of the project up to IMPD/IND application.
· Investigate efficacy, potency, immunotherapeutic activities, treatment combination, stability, PK/PD, translational research to provide data supporting the development of the candidates up to phase I clinical trial.
· Drive the scientific and technical content of research proposals to be implemented ‘in-house” and the scientific management of externalized R&D activities to an international panel of preclinical CROs, business partners, and academic collaborators, in tight collaboration with the R&D project manager to deliver on-time according to plan and within the budget constraints.
· Prepare study reports, develop, and implement technical documents including SOPs and qualification/validation protocols.
· Contribute to the writing of dossiers for fund raising through competitive grant applications, patent applications, and scientific publications. Present data internally and externally.
· Lead the discovery and validation of the future Skymab candidates by leveraging knowledge of antibody discovery, protein engineering, immuno-oncology and ADC technology to develop new therapeutics.
· Maintain broad knowledge of literature and state-of-the-art technology & support the CEO and the Director of Development in R&D meetings and bibliography research.
· Contribute with the CEO, the director of Development, the director of operations and R&D team to prepare the scientific sections in presentation and documents to be shared with key stakeholders.
· Identify patentable inventions.
Qualifications, experience
· A Master or PhD degree with hands-on experience in preclinical oncology, immuno-oncology models and molecular Biology and in vitro and in vivo pharmacology.
· Experience in basic molecular biology, biochemical, immunological analysis techniques (eg. FACS, T-cell assays, ELISA) and preclinical in vitro cell-based assay.
· Experience in in vivo oncology models (CDX, PDX, PDXO…), PoC, PK/PD, preclinical validation and characterization of therapeutic antibody candidates and ideally of ADCs is an asset.
· Proficiency with computing tools and software programs, eg. Prism, Geneious, Sequencher…
· Experience in antibody engineering and with bioinformatics tools is an asset.
· Experience and certification in animal experimentation (murine species) is mandatory.
· Experience in translational research project, biomarker, and clinical trial is an asset.
· Experience or good understanding of GPCR biology is a plus.
· Previous experience in R&D in industry, GLP, and people management is a plus.
Skills and values
· Deep scientific curiosity and motivation to innovate and advance new therapeutic modalities through the whole R&D process form bench to patient.
· High degree of autonomy with a can-do and hands-on attitude.
· Ability to work in a fast-paced biotech multi-disciplinary environment, adept at problem solving and with the flexibility required to organize, manage multiple projects simultaneously in a goal-oriented framework.
· Result-driven and prioritization spirit.
· Strong team-spirit to work with Skymab and CEA scientists in the laboratory as well as with remote Skymab team members and external partners.
· Proficient verbal and written communication skills both in French and in English to effectively produce technical and scientific documentation and present scientific data to international standards.
· Strong scientific work ethics and confidentiality awareness.
· Ability to create a learning environment, open to suggestions and experimentation for improvement.
· Accuracy for deliverables with strictness of running experimental procedures.
Remuneration
Attractive compensation package in line with experience and seniority and stock option plan (BSPCE or other form of participation to the company capital).
Applicants should send a cover letter, including a brief statement of research experience and interests (max 2 pages), their curriculum vitae, as well as the names and contact information of three references.
Please send your application to: Caroline MOULINE; [email protected]
Type d'emploi : Temps plein, CDI
Statut : Cadre
Rémunération : à partir de 27 345,15€ par an
Avantages :
- Intéressement et participation
Lieu du poste : En présentiel
Date de début prévue : 01/09/2025
